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Singapore Radiopharmaceuticals
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18F-Fluoromisonidazole [F-MISO]
  Noninvasive positron emission tomography (PET) imaging evaluates the tumor and regional disease in a ‘‘snapshot’’ fashion and can provide serial quantitative measurements of hypoxia. PET imaging of tissue hypoxia using 18F]fluoromisonidazole (FMISO), the most widely used nitroimidazole imaging agent, was developed few years ago. Positive accumulation of FMISO is proportional to the extent of hypoxia in the pO2 range of a few mm Hg; high FMISO uptake implies a low tissue O2 concentration. [18F]MISO is only sensitive to the presence of hypoxia in viable cells; [18F]MISO is not retained in necrosis because the electron transport chain that reduces the nitroimidazole to a bioreductive alkylating agent is no longer active.
 
  Some Applications of [18F] Fluoromisonidazole [F-MISO]
 
S.No Applications Resource
1 Tumor Hypoxia Imaging with [F-18] Fluoromisonidazole Positron Emission Tomography in Head and Neck Cancer Joseph G. Rajendran, et al.Clin Cancer Res., 2006, 12, 5435.
2 Assessment of hypoxia in esophageal carcinomas using 18F-MISO PET Ingo Brink, et al. J Nucl Med., 2008, 49 (Supplement 1), 113P
3 Hypoxia positron emission tomography imaging with 18F-fluoromisonidazole Lee ST, et al. Sem Nucl Med., 2007, 37, 451.
4 Quantifying regional hypoxia in human tumors with positron emission tomography of [18F] fluoromisonidazole: a pretherapy study of 37 patients Rasey JS, et al. Int J Radiat Oncol Biol Phys., 1996, 36, 417.
5 Regional hypoxia in glioblastoma multiforme quantified with [18F]fluoromisonidazole positron emission tomography before radiotherapy: correlation with time to progression and survival. Spence et al. Clin Cancer Res., 2008, 14, 2623.
6 pO polarography, contrast enhanced color duplex sonography(CDS), [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography: validated methods for the evaluation of therapy-relevant tumor oxygenation or only bricks in the puzzle of tumor hypoxia? Bernd Gagel, et al. BMC Cancer., 2007, 7 113.
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