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Singapore Radiopharmaceuticals
01-15/16 The Gemini, Science Park II
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Singapore 117610
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  11C Choline
  Recently, 11C-choline has been introduced as a new tumor-seeking agent for evaluation of a variety of malignant tumors. Choline is incorporated into cells through phosphorylcholine synthesis and is integrated into the cell membrane phospholipid. Malignant tumors may show a high proliferation and increased metabolism of cell membrane components, which will lead to an increased uptake of choline. This feature becomes an interesting targeting system for low-grade tumors such as hepatocellular carcinoma (HCC), where the enzymatic activity of low-grade HCC cells resembles that of normal hepatocytes, leading to very low uptake of [18F][FDG].  
   
  Some Applications of [11C] Choline
 
S.No Applications Resource
1 Detection of Hepatocellular Carcinoma Using 11CCholine PET: Comparison with 18F-FDG PET Yuka Yamamoto, et al. J Nucl Med., 2008, 49, 1245.
2 11C-Acetate as a PET Radiopharmaceutical for Imaging Fatty Acid Synthase Expression in Prostate Cancer Amy L. V vere , et al. J Nucl Med., 2008, 49, 327.
3 Imaging of Gynecologic Tumors: Comparison of 11C-Choline PET with 18F-FDG PET Tatsuo Torizuka, et al. J Nucl Med., 2003, 44, 1051.
4 Value of 11C-Choline PET and Contrast-Enhanced CT for Staging of Bladder Cancer: Correlation with Histopathologic Findings Maria Picchio, et al. J Nucl Med., 2006, 47, 938.
5 11C choline vs. 18F-FDG PET/CT in assessing bone involvement in patients with multiple myeloma Cristina Nanni, et al. World Journal of Surgical Oncology. 2007,5, 68.
6 PET imaging of brain tumor with [methyl-11C]choline. Hara T, et al.J Nucl Med. 1997, 38, 842.
 
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