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11C Choline
Recently, 11C-choline has been introduced as a new tumor-seeking agent for evaluation of a variety of malignant tumors. Choline is incorporated into cells through phosphorylcholine synthesis and is integrated into the cell membrane phospholipid. Malignant tumors may show a high proliferation and increased metabolism of cell membrane components, which will lead to an increased uptake of choline. This feature becomes an interesting targeting system for low-grade tumors such as hepatocellular carcinoma (HCC), where the enzymatic activity of low-grade HCC cells resembles that of normal hepatocytes, leading to very low uptake of [18F][FDG].
Some Applications of [11C] Choline
| S.No |
Applications |
Resource |
| 1 |
Detection of Hepatocellular Carcinoma Using 11CCholine PET: Comparison with 18F-FDG PET |
Yuka Yamamoto, et al. J Nucl Med.,2008, 49, 1245. |
| 2 |
11C-Acetate as a PET Radiopharmaceutical for Imaging Fatty Acid Synthase Expression in Prostate Cancer |
Amy L. V vere , et al. J Nucl Med., 2008, 49, 327. |
| 3 |
Imaging of Gynecologic Tumors: Comparison of 11C-Choline PET with 18F-FDG PET |
Tatsuo Torizuka, et al. J Nucl Med., 2003, 44, 1051. |
| 4 |
Value of 11C-Choline PET and Contrast-Enhanced CT forStaging of Bladder Cancer: Correlation with Histopathologic Findings |
Maria Picchio, et al. J Nucl Med., 2006, 47, 938. |
| 5 |
11C choline vs. 18F-FDG PET/CT in assessing bone involvement in patients with multiple myeloma |
Cristina Nanni, et al. World Journal of Surgical Oncology. 2007,5, 68. |
| 6 |
PET imaging of brain tumor with [methyl-11C]choline. |
Hara T, et al.J Nucl Med.1997, 38, 842. |
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