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  13N-Ammonia
  13N-Ammonia has been proved to be a good indicator of myocardial blood flow and a reflection of metabolic integrity. Metabolic trapping of 13N-ammonia in brain and myocardium occurs primarily via the glutamate-glutamine pathway. 13N-ammonia has been used extensively for the assessment of myocardial perfusion with PET. This tracer exhibits high, single-pass extraction by the myocardium and relatively prolonged retention in the heart. 13N- ammonia provides extremely high-quality images of the myocardium in most cases.  
   
  Some Applications of [13N] Ammonia
 
S.No Applications Resource
1 Absolute Quantification of Myocardial Blood Flow with 13N-Ammonia and 3-Dimensional PET Tiziano Schepis, et al. J Nucl Med., 2007, 48, 1173.
2 Quantification of regional myocardial blood flowusing 13N-Ammonia and reoriented dynamic positron emission tomographic imaging Kuhle WG, et al. Circulation. 1992, 86, 1004.
3 Gated Cardiac 13N-Ammonia PET for Assessment of Left Ventricular Volumes, Mass, and Ejection Fraction: Comparison with Electrocardiography-Gated 18F-FDG PET Aliasghar Khorsand, et al. J Nucl Med., 2005, 46, 2009.
4 PET Imaging of cerebral astrocytoma with 13N-Ammonia Xiangsong Z, et al. J Neurooncol., 2006, 78, 145.
5 Differentiation of recurrent astrocytoma from radiation necrosis : a pilot study with 13N-Ammonia PET Xiangsong Z, et al. J Neurooncol., 2007, 82, 305.
6 Dynamic 13N-ammonia PET: a new imaging method to diagnose hypopituitarism Xiangsong Z, et al. J Nucl Med., 2005, 46, 44.
 
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