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11C Acetate
11C-acetate has been used for several years to study oxidative metabolism of the myocardium. More recent studies have shown that 11C-acetate is also accumulated by various malignancies, including prostate cancer. Fatty acid synthase (FAS) is a multifunctional enzymatic protein that catalyzes fatty acid biosynthesis. FAS is overexpressed in prostate carcinomas as well as other cancers. On the other hand, FAS levels are low or absent in most normal tissues. FAS levels are associated with tumor aggressiveness in late-stage prostatic adenocarcinomas as well as a prognostic indicator for overall survival.11C-acetate is transported across the cell membrane by monocarboxylate carriers (MCT). The metabolic fate of acetate in cancer cells is fundamentally different from normal cells. In cancer cells, an anabolic pathway seems to dominate, which uses acetate for synthesis of fatty acids and lipids.
Some Applications of [11C] Acetate
| S.No |
Applications |
Resource |
| 1 |
11C-Acetate PET Imaging in Hepatocellular Carcinoma and Other Liver Masses |
Chi-Lai Ho, et al.J Nucl Med., 2003, 44, 213. |
| 2 |
11C-Acetate PET Imaging of Prostate Cancer |
Nobuyuki Oyama, et al. J Nucl Med., 2002, 43, 181. |
| 3 |
11C-acetate PET in the early evaluation of prostate cancer recurrence |
Susanne Albrecht, et al. Eur J Nucl Med Mol Imaging. 2007, 34, 185. |
| 4 |
11C-Acetate PET in the Evaluation ofBrain Glioma : Comparison with 11C-Methionine and 18F-FDG-PET |
Susanne Albrecht, et al. Eur J Nucl Med Mol Imaging. 2007, 34, 185. |
| 5 |
Measurement of Myocardial Blood Flow with PET Using 1-11C-Acetate |
Robert R. Sciacca. J Nucl Med., 2001,42, 63. |
| 6 |
11C-Acetate Positron Emission Tomography Imaging for Lung Adenocarcinoma 1 to 3 cm in Size With Ground-Glass Opacity Images on Computed Tomography |
Hiroaki Nomori, et al.Ann Thorac Surg., 2005, 80, 2020. |
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